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Zoloft ® (Sertraline HCL) is a selective serotonin reuptake inhibitor (SSRI) used to treat depression, panic attacks, obsessive compulsive disorders (OCD) and post-traumatic stress disorder. This medication works by helping to restore the balance of certain natural chemicals in the brain.

Zoloft ®


Product Dosage Qty Consult Price Order
  Zoloft 50 mg 30 Tabs FREE
  Zoloft 50 mg 90 Tabs FREE
  Zoloft 100 mg 30 Tabs FREE
  Zoloft 100 mg 60 Tabs FREE
  Zoloft 100 mg 90 Tabs FREE



Zoloft ® is manufactured by Pfizer Inc.

Chemical Name : Sertraline HCL

Important Note
The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.

Uses
Sertraline is used to treat depression, panic attacks, obsessive compulsive disorders (OCD), and post-traumatic stress disorder (PTSD). This medication works by helping to restore the balance of certain natural chemicals in the brain. This medication has also been used to treat a severe form of premenstrual syndrome (premenstrual dysphoric disorder- PMDD) and a sexual function problem in men (premature ejaculation).

How to Use
Take this medication by mouth usually once daily with or without food; or as directed by your doctor. It is recommended that you take your dosage at the same time each day, either in the morning or in the evening. The dosage is based on your medical condition and response to therapy. It is important to continue taking this medication as prescribed even if you feel well. Also, do not stop taking this medication without consulting your doctor. It may take up to 4 weeks before the full benefit of this drug takes effect.

Side Effects
Nausea, headache, diarrhea, trouble sleeping, dry mouth, drowsiness, dizziness, or upset stomach may occur. If any of these effects persist or worsen, notify your doctor promptly. Tell your doctor immediately if any of these serious side effects occur: loss of appetite, unusual weight loss, unusual or severe mental/mood changes, increased sweating/flushing, unusual fatigue, uncontrolled movements (tremor), decreased interest in sex. Tell your doctor immediately if any of these unlikely but serious side effects occur: vision changes, changes in sexual ability, painful and/or prolonged erection. Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: fainting, irregular heartbeat, chest pain, muscle pain, trouble swallowing, ringing in in the ears, seizures. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, severe dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions
Tell your doctor your medical history, especially of: liver problems, kidney disease, seizures, heart problems, any allergies. This drug may make you dizzy or drowsy; use caution engaging in activities requiring alertness such as driving or using machinery. Limit alcoholic beverages. Caution is advised when using this product in the elderly because they may be more sensitive to the effects of the drug. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. This drug passes into breast milk. Because of the potential risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

Drug Interactions
Certain medications taken with this product could result in serious, even fatal, drug interactions. Avoid taking MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, selegiline, tranylcypromine) within 2 weeks before or after treatment with this medication. Consult your doctor or pharmacist for additional information.

This drug is not recommended for use with: weight loss drugs (e.g., sibutramine, phentermine), terfenadine, astemizole. Ask your doctor or pharmacist for more details. Tell your doctor of all prescription and nonprescription medication you may use, especially: other SSRI antidepressants (e.g., citalopram, fluoxetine), nefazodone, venlafaxine, "triptan" migraine drugs (e.g., sumatriptan, zolmitriptan), tramadol, tricyclic antidepressants (e.g., amitriptyline, nortriptyline), cimetidine, flecainide, propafenone, clozapine, trazodone, lithium, tryptophan, "blood thinners" (e.g., warfarin), any herbal/natural products (e.g., melatonin, St John's wort, ayahuasca).

Tell your doctor if you take any drugs that cause drowsiness such as: medicine for sleep, sedatives, tranquilizers, anti- anxiety drugs (e.g., diazepam), narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., phenothiazines such as chlorpromazine), anti-seizure drugs (e.g., carbamazepine), muscle relaxants, certain antihistamines (e.g., diphenhydramine). Report other drugs which affect the heart rhythm (QTc prolongation), such as: dofetilide, pimozide, sotalol, quinidine, procainamide, sparfloxacin, "water pills" (diuretics such as furosemide or hydrochlorothiazide). Ask your doctor or pharmacist for more details. Do not start or stop any medicine without doctor or pharmacist approval.

Overdose
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include: irregular heartbeat, fainting, severe dizziness or lightheadedness.

Missed Dose
If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage
Store at room temperature between 59 and 86 degrees F (15 and 30 degrees C) away from light and moisture.

 

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 Other causes of depression : Certain medications that alter the levels of norepinephrine or serotonin can alleviate the symptoms of depression. Some medicines that affect both of these neurochemical systems appear to perform even better or faster. Other medications that treat depression primarily affect the other neurochemical systems. The most powerful treatment for depression, electroconvulsive therapy (ECT), is certainly not specific to any particular neurotransmitter system. Rather, ECT, by causing a seizure, produces a generalized brain activity that probably releases massive amounts of all of the neurochemicals. Women are twice as likely to become depressed as men. However, scientists do not know the reason for this difference. Psychological factors also contribute to a person's vulnerability to depression. Thus, persistent deprivation in infancy, physical or sexual abuse, clusters of certain personality traits, and inadequate ways of coping (maladaptive coping mechanisms) all can increase the frequency and severity of depressive disorders, with or without inherited vulnerability. The effect of maternal-fetal stress on depression is currently an exciting area of research. It seems that maternal stress during pregnancy can increase the chance that the child will be prone to depression as an adult, particularly if there is a genetic vulnerability. It is thought that the mother's circulating stress hormones can influence the development of the fetus's brain during pregnancy. This altered fetal brain development occurs in ways that predispose the child to the risk of depression as an adult. Further research is still necessary to clarify how this happens. Again, this situation shows the complex interaction between genetic vulnerability and environmental stress, in this case, the stress of the mother on the fetus.

Depression diagnosis : The first step to obtaining appropriate treatment is a complete physical and psychological evaluation to determine whether the person may have a depressive illness, and if so, what type. Certain medications, as well as some medical conditions, can cause symptoms of depression. Therefore, the examining physician should rule out (exclude) these possibilities through an interview, physical examination, and laboratory tests. A thorough diagnostic evaluation includes a complete history of the patient's symptoms: (1) When did the symptoms start? (2) How long have they lasted? (3) How severe are they? and (4) Have the symptoms occurred before, and, if so, were they treated and what treatment was received? The doctor should ask about alcohol and drug use, and whether the patient has had thoughts about death or suicide. Further, the history should include questions about whether other family members have had a depressive illness, and if treated, what treatments they received and which were effective. A diagnostic evaluation also includes a mental status examination to determine if the patient's speech, thought pattern, or memory has been affected, as often happens in the case of a depressive or manic-depressive illness. As of today, there is no laboratory test, blood test, or X-ray that can diagnose a mental disorder.

Symptoms of depression and mania : Not everyone who is depressed or manic experiences every symptom. Some people experience a few symptoms and some many symptoms. The severity of symptoms also varies with individuals. Depression Symptoms of Manic Depression : Persistently sad, anxious, or "empty" mood. Feelings of hopelessness, pessimism. Feelings of guilt, worthlessness, helplessness. Loss of interest or pleasure in hobbies and activities that were once enjoyed, including sex. Insomnia, early-morning awakening, or oversleeping. Decreased appetite and/or weight loss, or overeating and weight gain. Fatigue, decreased energy, being "slowed down." Thoughts of death or suicide, suicide attempts. Restlessness, irritability.

Types of depression : Depressive disorders come in different forms, just as do other illnesses, such as heart disease and diabetes. Three of the most common types of depressive disorders are discussed below. However, remember that within each of these types, there are variations in the number, severity, and persistence of symptoms. Major depression is characterized by a combination of symptoms, including sad mood (see symptom list), that interfere with the ability to work, sleep, eat, and enjoy once-pleasurable activities. Disabling episodes of depression can occur once, twice, or several times in a lifetime. Dysthymia is a less severe type of depression. It involves long-term (chronic) symptoms that do not disable, but yet prevent the affected person from functioning at "full steam" or from feeling good. Sometimes, people with dysthymia also experience episodes of major depression. This combination of the two types of depression is referred to as double-depression. Another type of depression is bipolar disorder, which was formerly called manic-depressive illness or manic depression. This condition shows a particular pattern of inheritance. Not nearly as common as the other types of depressive disorders, bipolar disorder involves cycles of depression and mania, or elation. Bipolar disorder is often a chronic, recurring condition. Sometimes, the mood switches are dramatic and rapid, but most often they are gradual. When in the depressed cycle, the person can experience any or all of the symptoms of a depressive disorder. When in the manic cycle, any or all of the symptoms listed under mania may be experienced. Mania often affects thinking, judgment, and social behavior in ways that cause serious problems and embarrassment. For example, unwise business or financial decisions may be made when an individual is in a manic phase.

 

 

 

 

 

20th August 2008