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Sonata ® (Zaleplon) belongs to the class of drugs called hypnotics, and is used for the short term treatment of sleep problems (insomnia). Hypnotics should generally be limited to 7 to 10 days of use. Reevaluation is recommended if hypnotics are taken for more than 2 to 3 weeks.



Sonata ® is manufactured by Lundbeck Limited.

Chemical Name : Zaleplon

Important Note
The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.

 

Uses
This medication is used for the short-term treatment of sleep problems (insomnia). Sonata (Zaleplon) belongs to a new group of medicines that are used to help individuals who have difficulty falling asleep. It selectively binds to a particular part of a receptor in the brain called GABA receptors. This causes the release of a chemical called GABA (gamma amino butyric acid). GABA is a major inhibitory chemical in the brain which is responsible for causing sleepiness and controlling anxiety and fits. By increasing GABA release, Zaleplon therefore helps individuals to fall asleep, as well as decreasing anxiety and relaxing the muscles.


How to Use
Take Sonata by mouth, immediately before bedtime or after you have gone to bed and have difficulty sleeping, as directed by your doctor. Do not take this medication with, or immediately after, a high-fat or heavy meal. Sonata helps you fall asleep. To minimize side effects while you are awake (e.g., dizziness or memory trouble), take this medication when you are in bed and are able to get at least four hours of sleep before you need to be active again. Do not use Sonata for longer than ten days without your doctor's approval. If your sleep problems continue, consult with your doctor. Use this medication exactly as prescribed. Do not increase your dose, take it more frequently or use it for a longer period of time than prescribed because this drug can be habit-forming. Also, if used for a longer period of time, do not stop using this medication without your doctor's approval.

Side Effects
Headache, drowsiness, nausea or stomach upset may occur. If any of these effects persist or worsen, notify your doctor promptly. Tell your doctor immediately if you have any of these serious side effects: dizziness, weakness, loss of coordination, muscle joint pain. Tell your doctor immediately if you have any of these unlikely but serious side effects: mental/mood changes, persistent trouble sleeping, memory problems, loss of appetite, tingling of the hands or feet, rash, itching, tremors, eye/ear problems. Tell your doctor immediately if you have any of these very unlikely but serious side effects: fast/slow/irregular pulse, chest pain, trouble breathing, blood in the stool, unusual thirst, change in amount of urine. If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions
Tell your doctor your medical history, including: allergies, liver disease, lung/breathing problems, mental/mood problems (e.g., depression), alcohol use or drug dependence. Avoid alcohol, as it may aggravate certain side effects of this drug (e.g., dizziness, drowsiness). Use caution when performing tasks requiring alertness (e.g., driving). You may have trouble sleeping the first few nights after you stop using this medication. This problem usually goes away after one or two nights. If sleep problems persist, consult with your doctor. Use with caution in the elderly, as they may be more sensitive to the effects of this medication. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. This medication passes into breast milk. Because of the potential risk to the infant, breast-feeding while using this medication is not recommended. Consult your doctor before breast- feeding.

Drug Interactions
Tell your doctor of all prescription and nonprescription medication you may use, especially of: rifamycin antibiotics (e.g., rifampin, rifabutin), antidepressants (e.g., imipramine, amitriptyline), ulcer medication (e.g., cimetidine). Also report any drugs causing drowsiness such as: other medicines for sleep, sedatives, tranquilizers, anti-anxiety drugs, narcotic pain relievers (e.g., codeine), psychiatric medications (e.g., thioridazine), anti-seizure medications (e.g., phenytoin, phenobarbital, carbamazepine), muscle relaxants, antihistamines that cause drowsiness (e.g., diphenhydramine). Check all medicine labels carefully, especially cough-and-cold preparations, since many contain antihistamines (e.g., diphenhydramine). Consult your pharmacist regarding safe use of these products. Do not start or stop any medicine without doctor or pharmacist approval.

Overdose
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include drowsiness; confusion; sluggishness; loss of coordination; slow, shallow breathing; and loss of consciousness.

Notes
Do not share this medication with others.

Missed Dose
Not applicable.

Storage
Store at room temperature between 68 and 77 degrees F (20 to 25 degrees C) away from light and moisture.

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 Insomnia Sleep Aids : Insomnia means difficulty in falling or staying asleep, the absence of restful sleep, or poor quality of sleep. Insomnia is a symptom and not a disease. The most common causes of insomnia are medications, psychological conditions (e.g., depression, anxiety), environmental changes (e.g., travel, jet lag, or altitude changes), and stressful events. Insomnia can also be caused by faulty sleeping habits such as excessive daytime naps or caffeine consumption. Insomnia may be classified by how long the symptoms are present. Transient insomnia usually is due to situational changes such as travel and stressful events. It lasts for less than a week or until the stressful event is resolved. Short-term insomnia lasts for 1-3 weeks, and long-term insomnia (chronic insomnia) continues for more than 3 weeks. Chronic insomnia often results from depression or substance abuse. Transient insomnia may progress to short- term insomnia and without adequate treatment, short-term insomnia may become chronic insomnia. Appropriate sleep habits are important in the management of insomnia. In some instances, changing sleep habits may correct the problem without the need for medications. Good sleep habits should include: Regular sleep times; A comfortable bed and quiet room at a comfortable temperature; Appropriate lighting; Regular exercise but not close to bedtime or late in the evening; A bedroom that is not used for work or other activities that are not related to sleep; Avoidance of stimulants (e.g. caffeine, tobacco), alcohol, and large meals close to bedtime; Relaxation techniques such as breathing exercises; and Avoidance of naps during the day. Self-treatment of insomnia with over-the-counter (OTC) drugs is advisable only for transient or short-term insomnia. OTC sleep aids should only be used for a short period of time in conjunction with changes in sleeping habits. Chronic use of these drugs may result in dependence on the them. This creates a situation in which sleep is not possible unless the drug is used. Chronic insomnia should be evaluated by a physician.

Insomnia: The perception or complaint of inadequate or poor-quality sleep because of one or more of the following: difficulty falling asleep; waking up frequently during the night with difficulty returning to sleep; waking up too early in the morning; or unrefreshing sleep. Insomnia is not defined by the number of hours of sleep a person gets or how long it takes to fall asleep. Individuals vary normally in their need for, and their satisfaction with, sleep. Insomnia may cause problems during the day, such as tiredness, a lack of energy, difficulty concentrating, and irritability.

Types of Insomnia: Insomnia can be classified as transient (short term), intermittent (on and off), and chronic (constant). Insomnia lasting from a single night to a few weeks is referred to as transient. If episodes of transient insomnia occur from time to time, the insomnia is said to be intermittent. Insomnia is considered to be chronic if it occurs on most nights and lasts a month or more. Causes of Insomnia: Certain conditions seem to make individuals more likely to experience insomnia. Examples of these conditions include: advanced age (insomnia occurs more frequently in those over age 60); female gender; and a history of depression. If other conditions (such as stress, anxiety, a medical problem, or the use of certain medications) occur along with the above conditions, insomnia is more likely. There are many causes of insomnia. Transient and intermittent insomnia generally occur in people who are temporarily experiencing one or more of the following: stress, environmental noise, extreme temperatures, a change in the surrounding environment, sleep/wake schedule problems such as those due to jet lag, or medication side effects. Chronic insomnia is more complex and often results from a combination of factors, including underlying physical or mental disorders. One of the most common causes of chronic insomnia is depression. Certain Behaviors: Behaviors that perpetuate insomnia in some people include: expecting to have difficulty sleeping and worrying about it, ingesting excessive amounts of caffeine, drinking alcohol or smoking cigarettes before bedtime, excessive napping in the afternoon or evening, and irregular or continually disrupted sleep/wake schedules. These behaviors may prolong existing insomnia, and they can also be responsible for causing the sleeping problem in the first place. Stopping these behaviors may eliminate the insomnia altogether. Who Has Insomnia? Insomnia is found in males and females of all age groups, although it seems to be more common in females (especially after menopause) and in the elderly. The ability to sleep, rather than the need for sleep, appears to decrease with advancing age.

Treatment of Insomnia : Treatment of Transient and Intermittent Insomnia may not require treatment since, by definition, the episodes of insomnia only last a few days at a time. For example, if insomnia is due to a temporary change in the sleep/wake schedule, as with jet lag, the person's biological clock will often get back to normal on its own. However, for some people who experience daytime sleepiness and impaired performance as a result of transient insomnia, the use of short-acting sleeping pills may improve sleep and next-day alertness. As with all drugs, there are potential side effects. The use of over-the-counter sleep medicines is not usually recommended for the treatment of insomnia. Treatment of Chronic Insomnia consists of : First, diagnosing and treating underlying medical or psychological problems. Identifying behaviors that may worsen insomnia and stopping (or reducing) them. Possibly using sleeping pills, although the long-term use of sleeping pills for chronic insomnia is controversial. A patient taking any sleeping pill should be under the supervision of a physician to closely evaluate effectiveness and minimize side effects. In general, these drugs are prescribed at the lowest dose and for the shortest duration needed to relieve the sleep-related symptoms. For some of these medicines, the dose must be gradually lowered as the medicine is discontinued because, if stopped abruptly, it can cause insomnia to occur again for a night or two. Trying behavioral techniques to improve sleep, such as relaxation therapy, sleep restriction therapy, and reconditioning. Relaxation Therapy: There are specific and effective techniques that can reduce or eliminate anxiety and body tension. As a result, the person's mind is able to stop "racing," the muscles can relax, and restful sleep can occur. It usually takes much practice to learn these techniques and to achieve effective relaxation. Sleep Restriction: Some people suffering from insomnia spend too much time in bed unsuccessfully trying to sleep. They may benefit from a sleep restriction program that at first allows only a few hours of sleep during the night. Gradually the time is increased until a more normal night's sleep is achieved. Reconditioning: Another treatment that may help some people with insomnia is to recondition them to associate the bed and bedtime with sleep. For most people, this means not using their beds for any activities other than sleep and sex. As part of the reconditioning process, the person is usually advised to go to bed only when sleepy. If unable to fall asleep, the person is told to get up, stay up until sleepy, and then return to bed. Throughout this process, the person should avoid naps and wake up and go to bed at the same time each day. Eventually the person's body will be conditioned to associate the bed and bedtime with sleep.

 

 

 

 

 

04th July 2008