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NAPROSYN ®

Naprosyn ® (Naproxen) is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and swelling (inflammation). Naprosyn ® (Naproxen) works by blocking the enzyme in your body that makes prostaglandins.

It is also used to treat headaches, muscle aches, backaches, tendonitis, bursitis, dental pain, menstrual cramps, arthritis, or gout. Naprosyn may be used to reduce fever, or relieve minor aches and pain due to the common cold or flu.

Tramaden is a safe, non-prescription pain relief medicine.

 
Naprosyn ®


Product Dosage Qty Consult Price Order
  Naprosyn 375 mg 30 Tabs FREE
  Naprosyn 375 mg 60 Tabs FREE
  Naprosyn 500 mg 30 Tabs FREE
  Naprosyn 500 mg 60 Tabs FREE
  Generic Naprosyn 375 mg 30 Tabs FREE
  Generic Naprosyn 375 mg 60 Tabs FREE
  Generic Naprosyn 500 mg 30 Tabs FREE
  Generic Naprosyn 500 mg 60 Tabs FREE



Naprosyn ® is manufactured by Roche.

Chemical Name : Naproxen

Important Note
The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.

Uses
Naprosyn ® (Naproxen) is an anti-inflammatory NSAID used for the management of mild to moderate pain, fever, and inflammation. They work by reducing the levels of prostaglandins, chemicals that are responsible for pain, fever and inflammation. Other members of this class include ibuprofen (Motrin), indomethacin (Indocin), nabumetone (Relafen) and several others.
Naproxen was approved by the FDA in December, 1991.


How to take this medication
Naprosyn (Naproxen) comes as a tablet to take by mouth. The usual adult dose is 250-500 mg twice daily using regular naproxen tablets. The usual dose for Naprosyn controlled release tablets is 750 to 1000 mg given once daily. Naprosyn (Naproxen) should be given with food to reduce upset stomach. Take Naprosyn (Naproxen) with a full glass of water and do not lie down for 30 minutes after taking Naprosyn (Naproxen).

Side Effects
The most common side effects from Naprosyn (Naproxen) are rash, ringing in the ears, headaches, dizziness, drowsiness, abdominal pain, nausea, diarrhea, constipation, heartburn, fluid retention and shortness of breath. Naprosyn (Naproxen) also may cause stomach and intestinal bleeding and ulcers. Sometimes, stomach ulceration and intestinal bleeding can occur without any abdominal pain. Black tarry stools, weakness, and dizziness upon standing may be the only signs of the bleeding. People who are allergic to other NSAIDs should not use Naprosyn (Naproxen).

Contact your Doctor immediately if you experience severe stomach pain, swelling of hands/feet, sudden or unexplained weight gain, ringing in the ears (tinnitus), vision changes, rapid/pounding heartbeat, easy bruising/bleeding, change in amount of urine, severe headache, very stiff neck, mental/mood changes, or persistent sore throat or fever. may infrequently cause serious (rarely fatal) bleeding from the stomach or intestines.

Precautions
In certain conditions (e.g., arthritis), it may take upto 2 weeks, taken regularly, for
Naprosyn (Naproxen) to work. Do not stop taking Naprosyn (Naproxen) without checking with your doctor. Naprosyn (Naproxen) may alter certain lab test results. Make sure laboratory personnel and your doctors know you use Naprosyn (Naproxen).

Naprosyn (Naproxen) may cause increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Naprosyn (Naproxen). Use a sunscreen or protective clothing if you must be outside for a prolonged period. Do not take Naprosyn (Naproxen) if you ever had any unusual or allergic reaction to aspirin, ibuprofen, celecoxib, or any other medicine used to treat pain, fever, swelling, or arthritis. Daily use of alcohol and tobacco, especially when combined with Naprosyn (Naproxen), will increase your risk for stomach bleeding.

The elderly may be more sensitive to the effects of
Naprosyn (Naproxen), especially stomach bleeding and kidney effects.

If you plan on becoming pregnant, discuss with your doctor the benefits and risks of using Naprosyn (Naproxen) during pregnancy; Naprosyn (Naproxen) should only be used when clearly needed during the first 6 months of pregnancy. Naprosyn (Naproxen) is not recommended for use during the last 3 months of pregnancy due to its potential for fetal harm. Naprosyn (Naproxen) is excreted in breast milk. If you are or will be breast-feeding, check with your doctor of pharmacist to discuss the risks to your baby.

Drug Interactions
Naprosyn (Naproxen) may reduce the blood pressure lowering effects of blood pressure medications. This may occur because prostaglandins play a role in the regulation of blood pressure. Individuals taking oral blood thinners or anticoagulants (e.g., warfarin) should avoid Naprosyn (Naproxen) because it also thins the blood, and excessive blood thinning may lead to bleeding.

When Naprosyn (Naproxen) is used in combination with aminoglycosides (e.g., gentamicin) the blood levels of the aminoglycoside may increase, presumably because the elimination of aminoglycosides from the body is reduced. This may lead to more aminoglycoside-related side effects.
Naprosyn (Naproxen) may increase the blood levels of lithium (Eskalith) by reducing the excretion of lithium by the kidneys. Increased levels of lithium may lead to lithium toxicity.

Naprosyn (Naproxen) can aggravate paranoid symptoms in patients with schizophrenia, and increase symptoms of mania in patients with manic-depressive disease. Cimetidine (Tagamet) can increase blood levels of Naprosyn (Naproxen) and its side effects. The sedative effect of the medication can possibly impair the mental and physical abilities required for driving or operating machinery.

Overdose
If overdose is suspected, contact your local poison control center or emergency room immediately.The following symptoms indicate an overdose: dizziness; fainting; fast heartbeat.

Missed Dose
If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not take a double dose to make up for a missed one.

Storage
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed.

 

 
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 Chronic Pain : Chronic pain is a progressive disease state of the nervous system caused by the overloading of the body's natural pain control systems. The disease is accompanied by changes in the chemical and anatomical makeup of the spinal cord. Chronic pain is a malignancy. When it goes untreated it increases in intensity and spreads to areas of the body previously unaffected, damaging the sufferer's health and functioning. Doctors ignore your chronic pain for reasons that have nothing to do with the seriousness of your condition. Untreated chronic pain will damage your health and cause you to develop multiple health problems. Inactivity due to ongoing pain will lead to increased incidence of hypertension, heart disease, breathing disorders, cancer, and diabetes. If the disease is untreated in its most serious form, untreated chronic pain leads to suicide.

Chronic pain medicines - Information : Many medicines can help pain, including the ones listed in this handout. Each one may have side effects. Some side effects can be serious. It is important to listen to your family doctor carefully when he or she tells you how to use your pain medicine. If you have questions about side effects or about how much medicine to take, ask your doctor or your pharmacist. Acetaminophen (one brand name: Tylenol) helps many kinds of chronic pain. Remember, many over-the-counter and prescription pain medicines have acetaminophen in them. If you are not careful, you could take more acetaminophen than is good for you. Taking too much acetaminophen can cause liver damage. If you often have to take more than two acetaminophen pills a day, tell your doctor. Nonsteroidal Anti-inflammatory Medicines - Other medicines that help with pain are called nonsteroidal anti-inflammatory medicines. Examples include ibuprofen (two brand names: Motrin, Advil) and naproxen (two brand names: Aleve [over-the-counter], and Naprosyn [prescription]). You can take these medicines just when you need them, or you can take them every day. When you take these medicines regularly, they build up in your blood to fight the pain of inflammation (swelling) and give general pain relief. Many of these medicines are available in low-dose forms without a prescription. You need to tell your doctor if you are taking any of these medicines regularly. If your doctor wants you to take one of these medicines, always take it with food or a glass of milk, because the most common side effects are related to the stomach. If you already are taking other pain medicines, do not take these medicines without talking to your doctor first.

Pharmacokinetic comparison of Naprosyn ( Naproxen ) as a once-daily controlled-release tablet and a twice-daily conventional tablet
The bioequivalence and absorption kinetics of Naprosyn ( Naproxen ) in a new controlled-release tablet (750 mg or 1,000 mg Naprosyn ( Naproxen )) administered once daily were determined relative to an equivalent dose of the conventional Naprosyn ( Naproxen ) tablet (375 mg or 500 mg Naprosyn ( Naproxen )) administered q12h. Naprosyn ( Naproxen ) was well absorbed from the controlled-release tablet (about 90%) compared with the conventional tablet. Once-daily administration of the controlled-release tablet resulted in equivalent trough concentrations of Naprosyn ( Naproxen ), and steady-state plasma concentrations were maintained within narrower limits than with twice-daily Naprosyn ( Naproxen ).

Effects of indomethacin, Naprosyn ( Naproxen ) and paracetamol on regional blood flow in rabbits
Ulcerogenic side-effects and prostaglandin-synthesis-inhibiting capacity are well documented in indomethacin treatment. According to recent works, indomethacin reduces gastrointestinal blood-flow. Naprosyn ( Naproxen ) and paracetamol, claimed to be prostaglandin-synthesis-inhibitors, have few ulcerogenic side effects. Results show that Naprosyn ( Naproxen ) and paracetamol are usually well tolerated in the gastrointestinal tract. None of the drugs tested influenced resting blood flow in muscles, tendons, bones, joints or synovial membranes.

 

 

 

 

 

20th August 2008