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LIPITOR ®

Lipitor ® (Atorvastatin) is used with diet changes - restriction of cholesterol and fat intake - to reduce the amount of cholesterol and certain fatty substances in your blood. Accumulation of cholesterol and fats along the walls of your arteries (a process known as atherosclerosis) decreases blood flow and, therefore, the oxygen supply to your heart, brain, and other parts of your body. Lowering your blood level of cholesterol and fats with Lipitor may help to prevent heart disease, angina (chest pain), strokes, and heart attacks.

Lipitor ®
  Product Ships Rx Price Order
Lipitor (Atorvastatin) 10mg 30 Tablets USA Free $129
Lipitor (Atorvastatin) 10mg 60 Tablets USA Free $219
Lipitor (Atorvastatin) 10mg 90 Tablets USA Free $309
Lipitor (Atorvastatin) 20mg 30 Tablets USA Free $169
Lipitor (Atorvastatin) 20mg 60 Tablets USA Free $299
Lipitor (Atorvastatin) 20mg 90 Tablets USA Free $429
Lipitor (Atorvastatin) 40mg 30 Tablets USA Free $169
Lipitor (Atorvastatin) 40mg 60 Tablets USA Free $299
Lipitor (Atorvastatin) 40mg 90 Tablets USA Free $429
Lipitor (Atorvastatin) 80mg 30 Tablets USA Free $169
Lipitor (Atorvastatin) 80mg 60 Tablets USA Free $299
Lipitor (Atorvastatin) 80mg 90 Tablets USA Free $429
Amlodipine / Atorvastatin x 30 5/10mg Global Free $29
Atorvastatin x 180 10mg Global Free $57
Atorvastatin x 180 20mg Global Free $89
Atorvastatin x 180 5MG Global Free $27
Atorvastatin x 30 10mg Global Free $10
Atorvastatin x 30 20mg Global Free $17
Atorvastatin x 30 40mg Global Free $34
Atorvastatin x 30 5MG Global Free $8
Atorvastatin x 360 10mg Global Free $99
Atorvastatin x 360 20mg Global Free $177
Atorvastatin x 60 10mg Global Free $20
Atorvastatin x 60 20mg Global Free $34
Atorvastatin x 60 40mg Global Free $64
Atorvastatin x 60 5MG Global Free $16
Atorvastatin x 720 10mg Global Free $197
Atorvastatin x 90 10mg Global Free $30
Atorvastatin x 90 20mg Global Free $51
Atorvastatin x 90 40mg Global Free $89
Atorvastatin x 90 5MG Global Free $24



Lipitor ® is the #1 prescribed cholesterol-lowering medicine prescribed in the U.S. and is manufactured by Pfizer Inc.

Chemical Name : Atorvastatin

Important Note
The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.

Uses
Lipitor (Atorvastatin) is used with dietary changes (restriction of cholesterol and fat intake) to reduce the amount of cholesterol and certain fatty substances in your blood. Accumulation of cholesterol and fats along the walls of your arteries (a process known as atherosclerosis) decreases blood flow and, therefore, the oxygen supply to your heart, brain, and other parts of your body. Lowering your blood level of cholesterol and fats with Lipitor may help to prevent heart disease, angina (chest pain), strokes, and heart attacks.

How to take this medication
Lipitor (Atorvastatin) comes as a tablet to take by mouth. Lipitor usually is taken once a day. Follow the Lipitor directions on your Lipitor prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Lipitor/atorvastatin exactly as directed. Do not take more or less of Lipitor or take Lipitor more often than prescribed by your doctor.

Continue to take Lipitor (Atorvastatin) even if you feel well. Do not stop taking Lipitor/atorvastatin without talking to your doctor.

Eat a low-cholesterol, low-fat diet. This kind of diet includes cottage cheese, fat-free milk, fish (not canned in oil), vegetables, poultry, egg whites, and polyunsaturated oils and margarines (corn, safflower, canola, and soybean oils). Avoid foods with excess fat in them such as meat (especially liver and fatty meat), egg yolks, whole milk, cream, butter, shortening, lard, pastries, cakes, cookies, gravy, peanut butter, chocolate, olives, potato chips, coconut, cheese (other than cottage cheese), coconut oil, palm oil, and fried foods.

Side Effects
Although side effects from Lipitor are not common, they can occur. Tell your doctor if any of these symptoms are severe or do not go away: gas, stomach pain or cramps, diarrhea, constipation, heartburn, headache, blurred vision, dizziness, rash or itching, upset stomach If you experience any of the following symptoms, call your doctor immediately: muscle pain, tenderness, muscle cramps or weakness with or without a fever.

Precautions
Do not take Lipitor without first talking to your doctor if you have liver disease. Before taking Lipitor, tell your doctor if you have a chronic muscular disease, require major surgery, or have a blood disorder. Tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially antacids; antifungal medications such as itraconazole (Sporanox) and ketoconazole (Nizoral); digoxin (Lanoxin); erythromycin; medications that suppress the immune system such as cyclosporine (Neoral, Sandimmune); oral contraceptives (birth control pills); other cholesterol-lowering medications such as cholestyramine (Questran), colestipol (Colestid), gemfibrozil (Lopid), and niacin (nicotinic acid); and vitamins.



Lipitor is in the FDA pregnancy category X. This means that Lipitor is known to cause birth defects if it is taken during pregnancy. Do not take Lipitor if you are pregnant or could become pregnant during treatment. It is not known whether Lipitor passes into breast milk. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

Drug Interactions
Tell your doctor of all nonprescription and prescription medication you may use, especially: other nasal products, other corticosteroids (e.g., prednisone). Do not start or stop any medicine without doctor or pharmacist approval.

Overdose
If overdose is suspected, contact your local poison control center or emergency room immediately.

Missed Dose
If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.

Storage
Store at room temperature between 36 and 77 degrees F (2 -25 degrees C) away from light and moisture.

 

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How can levels of HDL cholesterol be raised : The first step in increasing HDL cholesterol levels (and decreasing LDL/HDL ratios) is life style modification. When life style modifications are insufficient, medications are used. In prescribing medications or medication combinations, doctors have to take into account medication side effects as well as presence or absence of other abnormalities in cholesterol profiles. Regular aerobic exercise, loss of excess weight (fat), and cessation of cigarette smoking cigarettes will increase HDL cholesterol levels. Regular alcohol consumption (such as one drink a day) will also raise HDL cholesterol. However, there are different subclasses of HDL cholesterol which have varying degrees of effectiveness in preventing atherosclerosis. Alcohol is believed to increase the level of the less important subtype of HDL cholesterol. Because of other adverse health consequences of excessive alcohol consumption, alcohol is not recommended as a standard treatment for low HDL cholesterol. Medications that are effective in increasing HDL cholesterol include nicotinic acid (niacin), gemfibrozil (Lopid), estrogen, and to a lesser extent, the statin drugs (discussed below).

Risk factors for heart attacks : Abnormally low HDL cholesterol levels. The size of the LDL cholesterol particles in the blood may be too small. Scientists have found that the size of LDL cholesterol particles in the blood is predominantly genetically inherited. People who have small and dense LDL cholesterol particles have a higher risk of developing atherosclerosis and heart attacks than those who have larger and more buoyant particles. Elevated Lp(a) cholesterol levels. The level of Lp(a) cholesterol is also predominantly genetically inherited. Individuals with elevated levels of Lp(a) cholesterol have a higher rate of atherosclerosis and risk of heart attacks. Elevated homocysteine levels.

What are the statin drugs : The statins are the most widely used medications today in lowering LDL cholesterol. Most of the clinical trials that showed heart attack reduction and improved longevity used one of the statins as the cholesterol lowering medication. Statins are well tolerated with low side effect rates when used long term. Statins not only lower blood LDL cholesterol levels, they also help increase HDL cholesterol levels. The statin medicines that are now on pharmacy shelves in the U.S. (putting the brand name first in capital letters followed by the generic name in parentheses) are: Lescol (fluvastatin sodium) made by Novartis Lipitor (atorvastatin calcium) made by Parke-Davis and Pfizer Mevacor (lovastatin) made by Merck Pravachol (pravastatin sodium) made by Bristol-Myers Squibb Zocor (simvastatin) made by Merck The statins act by repressing or inhibiting an enzyme called HMG-CoA reductase. The role of this enzyme is the promotion of a chemical reaction early in the synthesis of cholesterol. By inhibiting HMG-CoA reductase, the statins hinder the production (synthesis) of cholesterol by the liver. Diminished synthesis of cholesterol in the liver in turn stimulates (increases) the activity of LDL receptors on the surface of liver cells. Increasing LDL receptor activity decreases LDL cholesterol levels in blood. Studies have conclusively established that lowering LDL cholesterol with diet and statins reduces the risk of a second heart attack. The prevention of recurrent heart attacks in patients who have already suffered a heart attack is called secondary prevention. Studies have also demonstrated that reducing LDL cholesterol with diet and statins reduces the risk of having the first heart attack. Prevention of heart attacks in those who have never had a heart attack is called primary prevention. Studies have also confirmed that reducing LDL cholesterol benefits both men and women. For more information regarding the side effects, precautions, and drug interactions of the various statins, please read the Statins article, and visit the Medications area.

Cholesterol is a fatty substance (a lipid) that is an important part of the outer lining (membrane) of cells in the body of animals. Cholesterol is also found in the blood circulation of humans. The cholesterol in a person's blood originates from two major sources, dietary intake and liver production. Dietary cholesterol comes mainly from meat, poultry, fish, and dairy products. Organ meats, such as liver, are especially high in cholesterol content, while foods of plant origin contain no cholesterol. After a meal, cholesterol is absorbed by the intestines into the blood circulation and is then packaged inside a protein coat. This cholesterol-protein coat complex is called a chylomicron. The liver is capable of removing cholesterol from the blood circulation as well as manufacturing cholesterol and secreting cholesterol into the blood circulation. After a meal, the liver removes chylomicrons from the blood circulation. In between meals, the liver manufactures and secretes cholesterol back into the blood circulation.

 

 

 

 

 

14th March 2010