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COLCHICINE

Colchicine is used in the treatment of acute gout, including acute attacks, tophi (collection of uric acid crystals in the tissues, especially around joints), joint destruction, and uric acid stones. In acute gout, there is a marked inflammatory response to the presence of uric acid crystals, causing severe pain, redness and swelling of the affected joints. Colchicine is useful in suppressing the inflammation of arthritis in acute gout.

 
Colchicine
  Product Ships Rx Price Order
Colchicine (Colchicine) 0.6mg 30 Tablets USA Free $44
Colchicine (Colchicine) 0.6mg 60 Tablets USA Free $49
Colchicine (Colchicine) 0.6mg 90 Tablets USA Free $54
Colchicine 120 X Tab(s) 0.5mg Global Free $44.17
Colchicine 180 X Tab(s) 0.5mg Global Free $65.18
Colchicine 60 X Tab(s) 0.5mg Global Free $25.25



Colchicine

Chemical Name : Colchicine

Important Note
The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.

Uses
Colchicine is used to treat chronic gout to treat acute flares of gouty arthritis and to prevent recurrent acute attacks. Colchicine is also used to treat the inflammation of pseudogout, and other uncommon diseases, such as familial Mediterranean fever, amyloidosis, and scleroderma.
Colchicine is not habit forming.

How to take this medication
Take Colchicine exactly as prescribed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. Colchicine should be taken with food.

Side Effects
The most common side effects of Colchicine involve the stomach and bowel and are dose related. These include nausea, vomiting, abdominal pain, and diarrhea. One of the most worrisome side effects of colchicine is that it can damage the bone marrow causing severe anemia and seriously low white blood counts, thereby increasing the risk of infections. All patients taking colchicine long-term require blood count monitoring. Colchicine can also cause hair loss, weakness, and nerve irritation.

Precautions
Colchicine can arrest cell division and is avoided in pregnancy because of possible adverse affects on fetal growth.
For similar reasons, it is generally avoided in children.

Overdose
If overdose is suspected, contact your local poison control center or emergency room immediately.The following symptoms indicate an overdose: dizziness; fainting; fast heartbeat.

Missed Dose
If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not take a double dose to make up for a missed one.

Storage
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed.

 

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 Why does Gout Occur
Gout is medical condition characterized by abnormally elevated levels of uric acid in the blood, recurring attacks of joint inflammation (arthritis), deposits of hard lumps of uric acid in and around the joints, and decreased kidney function and kidney stones. While Gout is often associated with an abnormally elevated blood uric acid level, it need not be. That is, the medical condition of Gout can exist in an individual, with or without an elevated uric acid level in that individual. This even holds true for an acute attack of gouty arthritis! So, it is important to understand that it may not necessarily be the level of the uric acid that brings on an acute attack of gout. Frequently, it is a rapid change of uric acid, either up or down, that seems to precipitate an acute attack.

Gout is condition that results from crystals of uric acid depositing in tissues of the body. Gout is a condition featuring abnormally elevated levels of uric acid in the blood, recurring attacks of joint inflammation (arthritis), deposits of hard lumps of uric acid in and around the joints, and decreased kidney function and kidney stones. Gout is sometimes referred to as the disease of kings because it has long been erroneously associated with the kind of overindulgence in food that only the rich and powerful could afford.

Induction of nephrotoxic serum nephritis and suppressive effect of Colchicine
Clinically used Colchicine is thought to suppress functions of PMN. Therefore, the therapeutic effect of Colchicine on NTS nephritis was examined. Urinary protein excretion and hyperazotemia were significantly suppressed by treatment with 60 microg kg (-1) of Colchicine. A NTS nephritis model was established, it was found that Colchicine may have a suppressive effect on the development of glomerular nephritis.

Gout : How it Affects your Body
Uric acid crystals can deposit in tiny fluid-filled sacs (bursae) around the joints. These urate crystals can incite inflammation in the bursae leading to pain and swelling around the joints, a condition called bursitis. In rare instances, gout leads to a more chronic type of joint inflammation which mimics rheumatoid arthritis. In chronic gout, nodular masses of uric acid crystals (tophi) deposit in different soft tissue areas of the body. Even though they are most commonly found as hard nodules around the fingers, at the tips of the elbows, and around the big toe, tophi nodules can appear anywhere in the body. They have been reported in unexpected areas such as in the ears, vocal cords, or even around the spinal cord!

 

 

 

 

 

02nd September 2010