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COLCHICINE

Colchicine is used in the treatment of acute gout, including acute attacks, tophi (collection of uric acid crystals in the tissues, especially around joints), joint destruction, and uric acid stones. In acute gout, there is a marked inflammatory response to the presence of uric acid crystals, causing severe pain, redness and swelling of the affected joints. Colchicine is useful in suppressing the inflammation of arthritis in acute gout.

 
Colchicine
  Product Ships Rx Price Order
Colchicine (Colchicine) 0.6mg 30 Tablets USA Free $44
Colchicine (Colchicine) 0.6mg 60 Tablets USA Free $49
Colchicine (Colchicine) 0.6mg 90 Tablets USA Free $54
Colchicine 120 x Tab(s) 0.5mg Global Free $44.17
Colchicine 180 x Tab(s) 0.5mg Global Free $65.18
Colchicine 60 x Tab(s) 0.5mg Global Free $25.25



Colchicine

Chemical Name : Colchicine

Important Note
The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.

Uses
Colchicine is used to treat chronic gout to treat acute flares of gouty arthritis and to prevent recurrent acute attacks. Colchicine is also used to treat the inflammation of pseudogout, and other uncommon diseases, such as familial Mediterranean fever, amyloidosis, and scleroderma.
Colchicine is not habit forming.

How to take this medication
Take Colchicine exactly as prescribed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. Colchicine should be taken with food.

Side Effects
The most common side effects of Colchicine involve the stomach and bowel and are dose related. These include nausea, vomiting, abdominal pain, and diarrhea. One of the most worrisome side effects of colchicine is that it can damage the bone marrow causing severe anemia and seriously low white blood counts, thereby increasing the risk of infections. All patients taking colchicine long-term require blood count monitoring. Colchicine can also cause hair loss, weakness, and nerve irritation.

Precautions
Colchicine can arrest cell division and is avoided in pregnancy because of possible adverse affects on fetal growth.
For similar reasons, it is generally avoided in children.

Overdose
If overdose is suspected, contact your local poison control center or emergency room immediately.The following symptoms indicate an overdose: dizziness; fainting; fast heartbeat.

Missed Dose
If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not take a double dose to make up for a missed one.

Storage
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed.

 

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 Gout and Hyperuricemia
Gout is condition that results from crystals of uric acid depositing in tissues of the body. Gout is characterized by an overload of uric acid in the body and recurring attacks of joint inflammation (arthritis). Chronic gout can lead to deposits of hard lumps of uric acid in and around the joints, decreased kidney function, and kidney stones. It is often related to an inherited abnormality in the body's ability to process uric acid.

Uric acid is a breakdown product of purines, that are part of many foods we eat. An abnormality in handling uric acid can cause attacks of painful arthritis (gout attack), kidney stones, and blockage of the kidney filtering tubules with uric acid crystals, leading to kidney failure. On the other hand, some patients may only develop elevated blood uric acid levels (hyperuricemia) without having arthritis or kidney problems. The term "gout" commonly is used to refer to the painful arthritis attacks.

Gout is widespread
Approximately one million people in the United States suffer from attacks of gout.Gout is nine times more common in men than in women. It predominantly attacks males after puberty, with a peak age of 75. In women, gout attacks usually occur after menopause. While an elevated blood level of uric acid (hyperuricemia) may indicate an increased risk of gout, the relationship between hyperuricemia and gout is unclear.

Many patients with hyperuricemia do not develop gout, while some patients with repeated gout attacks have normal or low blood uric acid levels. Among the male population in the United States, approximately ten percent have hyperuricemia. However, only a small portion of those with hyperuricemia will actually develop gout.

Understanding Gout
Gout causes sudden, mostly severe attacks of pain and tenderness, redness, warmth and swelling in some joints, according to the Arthritis Foundation. It usually affects one joint at a time -- often the big toe. Episodes develop very quickly, and the first episode often occurs at night. Episodes may be caused by drinking too much alcohol, eating too much of certain foods, surgery, sudden illness, crash diets or chemotherapy.

Gout results from a build-up in the body of too much uric acid, which forms crystals that deposit in joints and cause inflammation. Uric acid is a substance that normally forms when the body breaks down waste products called purines. Men older than 40 are at greatest risk, but it can affect anyone of any age. Women with gout usually develop it after menopause. Treatment options include diet, medications, and sometimes surgery.

Induction of nephrotoxic serum nephritis and suppressive effect of Colchicine
Clinically used Colchicine is thought to suppress functions of PMN. Therefore, the therapeutic effect of Colchicine on NTS nephritis was examined. Urinary protein excretion and hyperazotemia were significantly suppressed by treatment with 60 microg kg (-1) of Colchicine. A NTS nephritis model was established, it was found that Colchicine may have a suppressive effect on the development of glomerular nephritis.

 

 

 

 

 

09th February 2010