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COLCHICINE

Colchicine is used in the treatment of acute gout, including acute attacks, tophi (collection of uric acid crystals in the tissues, especially around joints), joint destruction, and uric acid stones. In acute gout, there is a marked inflammatory response to the presence of uric acid crystals, causing severe pain, redness and swelling of the affected joints. Colchicine is useful in suppressing the inflammation of arthritis in acute gout.

 
Colchicine


Product Dosage Qty Consult Price Order
  Colchicine 0.6 mg 30 Tabs FREE
  Colchicine 0.6 mg 60 Tabs FREE
  Colchicine 0.6 mg 90 Tabs FREE



Colchicine

Chemical Name : Colchicine

Important Note
The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.

Uses
Colchicine is used to treat chronic gout to treat acute flares of gouty arthritis and to prevent recurrent acute attacks. Colchicine is also used to treat the inflammation of pseudogout, and other uncommon diseases, such as familial Mediterranean fever, amyloidosis, and scleroderma.
Colchicine is not habit forming.

How to take this medication
Take Colchicine exactly as prescribed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. Colchicine should be taken with food.

Side Effects
The most common side effects of Colchicine involve the stomach and bowel and are dose related. These include nausea, vomiting, abdominal pain, and diarrhea. One of the most worrisome side effects of colchicine is that it can damage the bone marrow causing severe anemia and seriously low white blood counts, thereby increasing the risk of infections. All patients taking colchicine long-term require blood count monitoring. Colchicine can also cause hair loss, weakness, and nerve irritation.

Precautions
Colchicine can arrest cell division and is avoided in pregnancy because of possible adverse affects on fetal growth.
For similar reasons, it is generally avoided in children.

Overdose
If overdose is suspected, contact your local poison control center or emergency room immediately.The following symptoms indicate an overdose: dizziness; fainting; fast heartbeat.

Missed Dose
If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not take a double dose to make up for a missed one.

Storage
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed.

 

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 Colchicine decreases apoptotic cell death in chronic cyclosporine nephrotoxicity
Colchicine has been shown to prevent kidney injury in chronic cyclosporine nephrotoxicity; however, the mechanisms of its action are undetermined. The purpose of this study was to clarify whether Colchicine prevents cyclosporine-induced kidney injury by decreasing kidney-cell apoptosis. The decreased apoptotic cell death was closely correlated with improved renal tubulointerstitial fibrosis. These findings strongly suggest that a renoprotective effect of Colchicine on cyclosporine-induced nephrotoxicity is coassociated with a decrease in apoptotic cells.



Symptoms of Gout
The small joint at the base of the big toe is the most common site of an acute gout attack. Other joints affected include the ankles, knees, wrists, fingers, and elbows. Acute gout attacks are characterized by a rapid onset of pain in the affected joint followed by warmth, swelling, reddish discoloration, and marked tenderness. Tenderness can be intense so that even a blanket touching the skin over the affected joint can be unbearable.

Patients can develop fever with the acute gout attacks. These painful attacks usually subside in hours to days, with or without medication. In rare instances, an attack can last for weeks. Most patients with gout will experience repeated attacks of arthritis over the years.

Induction of nephrotoxic serum nephritis and suppressive effect of Colchicine
Clinically used Colchicine is thought to suppress functions of PMN. Therefore, the therapeutic effect of Colchicine on NTS nephritis was examined. Urinary protein excretion and hyperazotemia were significantly suppressed by treatment with 60 microg kg (-1) of Colchicine. A NTS nephritis model was established, it was found that Colchicine may have a suppressive effect on the development of glomerular nephritis.

Colchicine effect on the permeability of the whole epithelium and of isolated cells
The effect of 2 X 10(-5) M Colchicine on epithelial cells isolated from frog skins was investigated. The results support the view that Colchicine does not directly affect ADH action on membrane permeability, but influences some mechanism that controls ADH action on transepithelial transport. Intercellular junctions appear to be the location of such a mechanism.

 

 

 

 

 

20th August 2008