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COLCHICINE

Colchicine is used in the treatment of acute gout, including acute attacks, tophi (collection of uric acid crystals in the tissues, especially around joints), joint destruction, and uric acid stones. In acute gout, there is a marked inflammatory response to the presence of uric acid crystals, causing severe pain, redness and swelling of the affected joints. Colchicine is useful in suppressing the inflammation of arthritis in acute gout.

 
Colchicine
  Product Ships Rx Price Order
Colchicine (Colchicine) 0.6mg 30 Tablets USA Free $44
Colchicine (Colchicine) 0.6mg 60 Tablets USA Free $49
Colchicine (Colchicine) 0.6mg 90 Tablets USA Free $54
Colchicine 120 x Tab(s) 0.5mg Global Free $44.17
Colchicine 180 x Tab(s) 0.5mg Global Free $65.18
Colchicine 60 x Tab(s) 0.5mg Global Free $25.25



Colchicine

Chemical Name : Colchicine

 Important Note
The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.

Uses
Colchicine is used to treat chronic gout to treat acute flares of gouty arthritis and to prevent recurrent acute attacks. Colchicine is also used to treat the inflammation of pseudogout, and other uncommon diseases, such as familial Mediterranean fever, amyloidosis, and scleroderma. Colchicine is not habit forming.

How to take this medication
Take Colchicine exactly as prescribed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. Colchicine should be taken with food.

Side Effects
The most common side effects of Colchicine involve the stomach and bowel and are dose related. These include nausea, vomiting, abdominal pain, and diarrhea. One of the most worrisome side effects of colchicine is that it can damage the bone marrow causing severe anemia and seriously low white blood counts, thereby increasing the risk of infections. All patients taking colchicine long-term require blood count monitoring. Colchicine can also cause hair loss, weakness, and nerve irritation.

Precautions
Colchicine can arrest cell division and is avoided in pregnancy because of possible adverse affects on fetal growth. For similar reasons, it is generally avoided in children.

Overdose
If overdose is suspected, contact your local poison control center or emergency room immediately.The following symptoms indicate an overdose: dizziness; fainting; fast heartbeat.

Missed Dose
If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not take a double dose to make up for a missed one.

Storage
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed.

 

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 Gout : Treatment by lowering Uric Acid Levels
In addition to medications for acute gout attacks, other drugs can be taken over prolonged periods to lower blood uric acid levels. Lowering blood uric acid levels reduces the risk of recurrent attacks of arthritis, kidney stones, and kidney disease, and also dissolves hard tophi deposits. Medicines used to lower blood uric acid level work either by increasing the kidney excretion of uric acid, or by decreasing the body's production of uric acid from the purine in foods. These medicines are generally not started until after the inflammation from acute gouty arthritis has subsided because they can worsen the attack. If they are already being taken prior to the attack, they are continued and only adjusted after the attack has resolved. Since many patients with elevated blood uric acid levels may not develop gouty attacks or kidney stones, the decision for prolonged treatment with uric acid-lowering drugs should be individualized.

Biliary excretion of Colchicine in newborn rats
In an attempt to determine the mechanism of the increased sensitivity of the newborn rat to the toxic action of Colchicine, the distribution of 3H after the administration of 3H-Colchicine (0.1 mg/kg) was measured in 10- and 35-day-old rats. The concentration of 3H was higher in all tissues of the newborn than the adult after ip administration, suggesting an immaturity in the pathway for Colchicine elimination. The results suggest that Colchicine is more toxic in the newborn because the drug remains in the body for a longer time due to immaturity of the liver excretory process.

Gout : Dietary Changes Required
Alcohol can also affect uric acid metabolism and cause hyperuricemia. Prevention of acute gout involves maintaining adequate fluid intake, weight reduction, dietary changes, reduction in alcohol consumption, and medications to reduce hyperuricemia. Maintaining adequate fluid intake helps prevent acute gout attacks. Adequate fluid intake also decreases the risk of kidney stone formation in patients with gout.

Dietary changes can help reduce uric acid levels in the blood. Since purine chemicals are converted by the body into uric acid, purine rich foods are avoided. Examples of foods rich in purine include shellfish and organ meats, such as liver, brains, kidneys, and sweetbreads. Researchers have reported, in general, that meat or seafood consumption increases the risk of gout attacks, while dairy consumption seemed to reduce the risk! Protein intake or purine-rich vegetable consumption was not associated with an increased risk of gout. Weight reduction can be helpful in lowering the risk of recurrent attacks of gout. This is best accomplished by reducing dietary fat and calorie intake, combined with a regular aerobic exercise program.

Gout is condition that results from crystals of uric acid depositing in tissues of the body. Gout is a condition featuring abnormally elevated levels of uric acid in the blood, recurring attacks of joint inflammation (arthritis), deposits of hard lumps of uric acid in and around the joints, and decreased kidney function and kidney stones. Gout is sometimes referred to as the disease of kings because it has long been erroneously associated with the kind of overindulgence in food that only the rich and powerful could afford.

 

 

 

 

 

11th March 2010