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Colchicine decreases apoptotic cell death in chronic cyclosporine nephrotoxicity Symptoms of Gout The small joint at the base of the big toe is the most common site of an acute gout attack. Other joints affected include the ankles, knees, wrists, fingers, and elbows. Acute gout attacks are characterized by a rapid onset of pain in the affected joint followed by warmth, swelling, reddish discoloration, and marked tenderness. Tenderness can be intense so that even a blanket touching the skin over the affected joint can be unbearable. Patients can develop fever with the acute gout attacks. These painful attacks usually subside in hours to days, with or without medication. In rare instances, an attack can last for weeks. Most patients with gout will experience repeated attacks of arthritis over the years. Induction of nephrotoxic serum nephritis and suppressive effect of Colchicine Clinically used Colchicine is thought to suppress functions of PMN. Therefore, the therapeutic effect of Colchicine on NTS nephritis was examined. Urinary protein excretion and hyperazotemia were significantly suppressed by treatment with 60 microg kg (-1) of Colchicine. A NTS nephritis model was established, it was found that Colchicine may have a suppressive effect on the development of glomerular nephritis. Colchicine effect on the permeability of the whole epithelium and of isolated cells The effect of 2 X 10(-5) M Colchicine on epithelial cells isolated from frog skins was investigated. The results support the view that Colchicine does not directly affect ADH action on membrane permeability, but influences some mechanism that controls ADH action on transepithelial transport. Intercellular junctions appear to be the location of such a mechanism. |
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20th August 2008
