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Cipro || Ciprofloxacin
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CIPRO ®

Cipro ® (Ciprofloxacin ) is a powerful and versatile antibiotic used to treat adults with infections caused by certain bacteria. Cipro is also widely used to prevent or slow the progress of the disease Anthrax after exposure.

Cipro ®


Product Dosage Qty Consult Price Order
  Cipro 250 mg 14 Tabs FREE No Stock
  Cipro 250 mg 20 Tabs FREE No Stock
  Cipro 500 mg 14 Tabs FREE No Stock
  Cipro 500 mg 20 Tabs FREE No Stock
  Cipro 750 mg 14 Tabs FREE No Stock
  Cipro 750 mg 20 Tabs FREE No Stock
  Generic Cipro 250 mg 14 Tabs FREE No Stock
  Generic Cipro 250 mg 20 Tabs FREE No Stock
  Generic Cipro 500 mg 14 Tabs FREE No Stock
  Generic Cipro 500 mg 20 Tabs FREE No Stock
  Generic Cipro 750 mg 14 Tabs FREE No Stock
  Generic Cipro 750 mg 20 Tabs FREE No Stock



Cipro ® is manufactured by Bayer.

Chemical Name : Ciprofloxacin

Important Note
The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.

Uses
Cipro (Ciprofloxacin) stops multiplication of bacteria by inhibiting the reproduction and repair of their genetic material (DNA). Cipro (Ciprofloxacin) is used to treat infections of the skin, lungs, airways, bones, and joints caused by susceptible bacteria. Cipro (Ciprofloxacin) is also frequently used to treat urinary infections caused by bacteria such as E.coli. This antibiotic is also FDA-approved for treatment of anthrax.

How to take this medication
Cipro (Ciprofloxacin) may be taken with or without meals; the preferred dosing time is 2 hours after a meal. Drink plenty of liquids while taking this medicine and take antacids that contain magnesium, aluminum, or calcium; iron; zinc;sucralfate; or didanosine chewable tablets or oral solution 2 hours after or 6 hours before taking this medicine. Do not take Cipro (Ciprofloxacin) with yogurt or milk alone. However, calcium as part of a meal does not affect this medicine. Do not consume products that contain caffeine (coffee, tea, cola) while taking Cipro (Ciprofloxacin).

Side Effects
Every medicine can cause side effects, but many people have no, or minor, side effects. Common side effects include nausea, diarrhea, headache, restlessness, stomach pain/cramps, rash,vomiting, headache, anxiety, nightmares. Contact your doctor or pharmacist if any of the following occurs: Convulsions, increased pressure within the head, dizziness, suicidal thoughts; hallucinations, loss of consciousness, tingling, severe allergic reactions (hives; itching; difficulty breathing, swelling of the face, tongue or lips), sleeplessness, bloody stools, yellowing of the skin or eyes, fatigue.

Failure to take all of the medicine may prevent complete elimination of bacteria, allowing the infection to return. If severe diarrhea, stomach cramps/pain, or bloody stools occurs, immediately contact your health care provider at once. This could be a sign of a serious side effect requiring immediate medical attention. Do not treat diarrhea without talking to your doctor.

Precautions
Before using Cipro (Ciprofloxacin), tell your health care provider about any of the following: if you are pregnant, planning to become pregnant, or breastfeeding; if you are taking any prescription medicine, nonprescription medicine, herbal preparation, or dietary supplement; if you have a history of hardening of the arteries in the brain; if you have gonorrhea; if you have impaired kidney function; if you have a history of seizures; if you are taking warfarin; if you are taking theophylline or you consume large amounts of caffeine.

Overdose
If overdose is suspected, contact your local poison control center or emergency room immediately.

Missed Dose
If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not take a double dose to make up for a missed one.

Storage
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed.

 

 
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 Pharmacokinetic aspects of treating infections in the intensive care unit: focus on drug interactions.

Pharmacokinetic interactions involving anti-infective drugs may be important in the intensive care unit (ICU). Although some interactions involve absorption or distribution, the most clinically relevant interactions during anti-infective treatment involve the elimination phase. Cytochrome P450 (CYP) 1A2, 2C9, 2C19, 2D6 and 3A4 are the major isoforms responsible for oxidative metabolism of drugs. Macrolides (especially troleandomycin and erythromycin versus CYP3A4), fluoroquinolones (especially enoxacin, Ciprofloxacin (Cipro) and norfloxacin versus CYP1A2) and azole antifungals (especially fluconazole versus CYP2C9 and CYP2C19, and ketoconazole and itraconazole versus CYP3A4) are all inhibitors of CYP-mediated metabolism and may therefore be responsible for toxicity of other coadministered drugs by decreasing their clearance. On the other hand, rifampicin is a nonspecific inducer of CYP-mediated metabolism (especially of CYP2C9, CYP2C19 and CYP3A4) and may therefore cause therapeutic failure of other coadministered drugs by increasing their clearance. Drugs frequently used in the ICU that are at risk of clinically relevant pharrmacokinetic interactions with anti-infective agents include some benzodiazepines (especially midazolam and triazolam), immunosuppressive agents (cyclosporin, tacrolimus), antiasthmatic agents (theophylline), opioid analgesics (alfentanil), anticonvulsants (phenytoin, carbamazepine), calcium antagonists (verapamil, nifedipine, felodipine) and anticoagulants (warfarin). Some lipophilic anti-infective agents inhibit (clarithromycin, itraconazole) or induce (rifampicin) the transmembrane transporter P-glycoprotein, which promotes excretion from renal tubular and intestinal cells. This results in a decrease or increase, respectively, in the clearance of P-glycoprotein substrates at the renal level and an increase or decrease, respectively, of their oral bioavailability at the intestinal level. Hydrophilic anti-infective agents are often eliminated unchanged by renal glomerular filtration and tubular secretion, and are therefore involved in competition for excretion. Beta-lactams are known to compete with other drugs for renal tubular secretion mediated by the organic anion transport system, but this is frequently not of major concern, given their wide therapeutic index. However, there is a risk of nephrotoxicity and neurotoxicity with some cephalosporins and carbapenems. Therapeutic failure with these hydrophilic compounds may be due to haemodynamically active coadministered drugs, such as dopamine, dobutamine and furosemide, which increase their renal clearance by means of enhanced cardiac output and/or renal blood flow. Therefore, coadministration of some drugs should be avoided, or at least careful therapeutic drug monitoring should be performed when available. Monitoring may be especially helpful when there is some coexisting pathophysiological condition affecting drug disposition, for example malabsorption or marked instability of the systemic circulation or of renal or hepatic function.

 

 

 

 

 

20th August 2008