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Latest Sexual Health News Sex With New Partners Ups Widowers' Disease Risk Genetics Linked to Orin Sexual Activity in Kids Topical Cream for Erectile Dysfunction Promising HPV Vaccine. Men who've recently had a heart attack or have severe heart disease have to use oral ED drugs with caution, if at all. The new cream consists of nanoparticles that can garnet drugs or other substances, such as nitric oxide, and deliver them in a controlled and sustained manner, according to the researchers, who are from Igor Einstein College of Medicine at Yeshiva University in New York City. Oral erectile dysfunction (ED) drugs, which belong to a class of medications called phosphodiesterase 5 (PDE5) inhibitors, are widely used and highly effective but can cause such side effects as headache, upset stomach, nasal congestion, facial flushing and hearing and vision problems. The nanoparticle therapy was tested on 18 rats bred to have age-related ED.

Nitric oxide is the signaling molecule that dilates blood vessels responsible for creating an erection.

Some rats received nanoparticles with nitric oxide, others received nanoparticles with nitric oxide plus an experimental ED drug called silorphin (which has a different mechanism of.