Itraconazole has been shown to be effective with a pulse dosing regimen, which means the medication is taken daily for one week and not taken for 3 weeks, repeating the pulsing three times.

This regimen reduces the cost of the medication when compared to a daily dose for 12 weeks. 250 mg/day for 4 weeks follo by 4 weeks of no terbinafine and then 4 weeks of terbinafine 250 mg/day. Terbinifine has classically been prescribed as a continuous dose, the treatment regimen is 250 mg per day for 12 weeks. Intermittent Terbinafine For Treatment of Toenail Fungus Terbinafine (Lamisil ) and itraconazole (Sporanox ) are both popular oral medications for the treatment of fungal toenail. The participants were follo for 72 weeks and mycological cure rates were found to be 83% for the pulse terbinafine group, 78% cure rate for the continuous terbinafine group and 56% for the pulse itraconazole group.

Minimal adverse events were recorded. These medications are expensive and the treatment regimen typically involves 3 months of therapy. In a recent study, the The three treatments regimens were as follows.

Pulse of 200 mg twice daily for 7 days on, 21 days off, 7 days on, 21 days off, 7 days on (total of 3 pulses).