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AMITRIPTYLINE (Generic Elavil )

Amitriptyline (Generic Elavil ) is an antidepressant medicine. In some patients with depression, abnormal levels of brain chemicals called neurotransmitters may relate to their depression. Amitriptyline (Generic Elavil ) elevates mood by raising the level of neurotransmitters in brain tissue.

 
Amitriptyline


Product Dosage Qty Consult Price Order
  Amitriptyline (gen. Elavil) 25 mg 30 Tabs FREE
  Amitriptyline (gen. Elavil) 25 mg 60 Tabs FREE
  Amitriptyline (gen. Elavil) 25 mg 90 Tabs FREE
  Amitriptyline (gen. Elavil) 25 mg 30 Tabs FREE
  Amitriptyline (gen. Elavil) 25 mg 60 Tabs FREE
  Amitriptyline (gen. Elavil) 25 mg 90 Tabs FREE
  Amitriptyline (gen. Elavil) 25 mg 30 Tabs FREE
  Amitriptyline (gen. Elavil) 25 mg 60 Tabs FREE
  Amitriptyline (gen. Elavil) 25 mg 90 Tabs FREE
  Amitriptyline (gen. Elavil) 25 mg 30 Tabs FREE
  Amitriptyline (gen. Elavil) 25 mg 60 Tabs FREE
  Amitriptyline (gen. Elavil) 25 mg 90 Tabs FREE
  Amitriptyline (gen. Elavil) 25 mg 30 Tabs FREE
  Amitriptyline (gen. Elavil) 25 mg 60 Tabs FREE
  Amitriptyline (gen. Elavil) 25 mg 90 Tabs FREE



Amitriptyline is Generic Elavil

Chemical Name : Amitriptyline

 Important Note
The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.

Uses
Amitriptyline (Generic Elavil ) is used to elevate the mood of patients with depression. Amitriptyline is also a sedative, and is useful in depressed patients with insomnia, restlessness, and nervousness. It has also been found to be helpful for treating fibromyalgia and symptoms related to chronic pain.

How to take this medication
Amitriptyline comes as a tablet to take by mouth, taken with or without food. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Amitriptyline exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Side Effects
Common side effects from Amitriptyline : upset stomach; drowsiness; weakness or tiredness; excitement or anxiety; insomnia or nightmares; dry mouth; skin more sensitive to sunlight than usual; changes in appetite or weight, fast heart rate, blurred vision, urinary retention, constipation, weight gain or loss, low blood pressure on standing.

Rash, hives, seizures, and hepatitis are rare side effects.

Precautions
Amitriptyline is metabolized by the liver and should be used with caution in patients with liver dysfunction.

Drug Interactions
Amitriptyline should not be used with Monoamine Oxidase inhibiting drugs. High fever, convulsions and even death can occur when these two drugs are used together. Epinephrine should not be used with amitriptyline, since together they can cause severe high blood pressure.

Amitriptyline is used with caution in patients with seizures, since it can increase the risk of seizures. Amitriptyline is used with caution in patients with prostate enlargement because of risk of urine retention. Amitriptyline can cause elevated pressure in the eyes of certain patients with glaucoma. Alcohol blocks the antidepressant action of Amitriptyline but increases its sedative effect.

Amitriptyline can aggravate paranoid symptoms in patients with schizophrenia, and increase symptoms of mania in patients with manic-depressive disease. Cimetidine (Tagamet) can increase blood levels of Amitriptyline and its side effects. The sedative effect of the medication can possibly impair the mental and physical abilities required for driving or operating machinery.

Overdose
Overdose with Amitriptyline can cause life threatening abnormal heart rhythms.If overdose is suspected, contact your local poison control center or emergency room immediately.The following symptoms indicate an overdose: dizziness; fainting; fast heartbeat.

Missed Dose
If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not take a double dose to make up for a missed one.

Storage
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed.

 

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 Comparative single-dose kinetics of Elavil ( Amitriptyline ) and its N-oxide
Plasma drug levels and urinary metabolites were measured in a volunteer for 28 h after ingestion of Elavil ( Amitriptyline ) hydrochloride or Elavil ( Amitriptyline ) N-oxide (amitriptylinoxide) equivalent to 100 mg of Elavil ( Amitriptyline ) base. From comparison of the metabolite excretions, it can be concluded that about 70% of the dose was reduced at the N-oxide group, while comparison of the areas under the plasma group, while comparison of the areas under the plasma level-time curves for Elavil ( Amitriptyline ) pointed to a 55% reduction to the amine. Less drowsiness was experienced after ingesting the N-oxide, and there was no depressive mood.

Frequency-dependent effects of Elavil ( Amitriptyline ) on ventricular conduction and cardiac rhythm
Although overdoses of tricyclic antidepressant are known to produce both sinus tachycardia and ventricular tachyarrhythmias in man, these have been assumed to occur by independent mechanisms. This study was designed to evaluate the relationship of ventricular activation frequency to the cardiotoxic effects of Elavil ( Amitriptyline ). studies show that Elavil ( Amitriptyline ) produces frequency-related depression of ventricular conduction in vivo, with a time dependence similar to effects on the maximum rate of depolarization in vitro. Interventions that slow heart rate reverse the adverse effects of Elavil ( Amitriptyline ) on ventricular conduction and cardiac rhythm.

Pharmacokinetic interaction between Elavil ( Amitriptyline ) and neuroleptics
The influence of Elavil ( Amitriptyline ) on the plasma level of various neuroleptics was studied in chronic schizophrenic patients. Patients were kept first 4 weeks on their former neuroleptic medication, with Elavil ( Amitriptyline ) added for 12 subsequent weeks, and withdrawn during the last 4 weeks when only the neuroleptic medication was continued unchanged. Elavil ( Amitriptyline ) provoked some increase of the plasma level of all phenothiazine derivatives. This augmentation was significant only transitorily, however.

Other causes of depression : Certain medications that alter the levels of norepinephrine or serotonin can alleviate the symptoms of depression. Some medicines that affect both of these neurochemical systems appear to perform even better or faster. Other medications that treat depression primarily affect the other neurochemical systems. The most powerful treatment for depression, electroconvulsive therapy (ECT), is certainly not specific to any particular neurotransmitter system. Rather, ECT, by causing a seizure, produces a generalized brain activity that probably releases massive amounts of all of the neurochemicals. Women are twice as likely to become depressed as men. However, scientists do not know the reason for this difference. Psychological factors also contribute to a person's vulnerability to depression. Thus, persistent deprivation in infancy, physical or sexual abuse, clusters of certain personality traits, and inadequate ways of coping (maladaptive coping mechanisms) all can increase the frequency and severity of depressive disorders, with or without inherited vulnerability. The effect of maternal-fetal stress on depression is currently an exciting area of research. It seems that maternal stress during pregnancy can increase the chance that the child will be prone to depression as an adult, particularly if there is a genetic vulnerability. It is thought that the mother's circulating stress hormones can influence the development of the fetus's brain during pregnancy. This altered fetal brain development occurs in ways that predispose the child to the risk of depression as an adult. Further research is still necessary to clarify how this happens. Again, this situation shows the complex interaction between genetic vulnerability and environmental stress, in this case, the stress of the mother on the fetus.

 

 

 

 

 

20th August 2008